Taking glucosamine sulfate and acetaminophen together could reduce the effectiveness of both the supplement and the medication. Taking glucosamine alone or in combination with the chondroitin supplement could increase the effects of the anticoagulant warfarin. This can increase the risk of bleeding. Glucosamine may interfere with some medications.
Do not use glucosamine if you are taking warfarin (Coumadin). Doing so increases the risk of bruising and dangerous bleeding. The supplement is usually sold in tablets and capsules and is often included with other supplements that may be effective for pain. Patients should always consult a health professional before changing their diet or taking any over-the-counter medication or nutritional supplement (also known as dietary supplements or natural supplements).
